Original Articles
Agreement between neutrophil/lymphocyte ratio and procalcitonin for determining severe community acquired pneumonia in children
Authors:
I Gusti Ayu Dwi Aryani ,
Medical School of Udayana University, Sanglah Hospital, Denpasar, Bali, ID
About I Gusti
Department of Paediatrics
Ayu Setyorini Mestika Mayangsari,
Medical School of Udayana University, Sanglah Hospital, Denpasar, Bali, ID
About Ayu
Department of Paediatrics
Eka Gunawijaya,
Medical School of Udayana University, Sanglah Hospital, Denpasar, Bali, ID
About Eka
Department of Paediatrics
Made Kardana,
Medical School of Udayana University, Sanglah Hospital, Denpasar, Bali, ID
About Made
Department of Paediatrics
I Gusti Ngurah Sanjaya Putra,
Medical School of Udayana University, Sanglah Hospital, Denpasar, Bali, ID
About I Gusti
Department of Paediatrics
I Nyoman Budi Hartawan,
Medical School of Udayana University, Sanglah Hospital, Denpasar, Bali, ID
About I Nyoman
Department of Paediatrics
Anak Agung Ngurah Ketut Putra Widnyana
Medical School of Udayana University, Sanglah Hospital, Denpasar, Bali, ID
About Anak
Department of Paediatrics
Abstract
Introduction: The use of inflammatory markers, such as procalcitonin, in assessing the severity of community acquired pneumonia (CAP) is limited by its relatively high cost. Currently, the Neutrophil/Lymphocyte ratio (NLR) is considered to have an important role in the inflammatory process.
Objectives: To evaluated the agreement between NLR and procalcitonin for determining severe CAP in children.
Method: This was a cross-sectional study carried out in children aged 2 months to 18 years with CAP in the paediatric unit at Sanglah Hospital, Denpasar, Bali, Indonesia from August 2019 – March 2021. Statistical analysis was performed using ROC to find the cut-off point of NLR. Analysis was performed to determining severe CAP based on cut-off points of procalcitonin and NLR. Cohen’s Kappa analysis between NLR and procalcitonin was performed for determining severe CAP with significant p-value <0.05.
Results: There were 58 subjects analysed in this study. Analysis performed by ROC showed cut off point of NLR was 2.11 with sensitivity of 82.4% and specificity of 83.3% while procalcitonin had a cut-off point of 1 ng/ml with a sensitivity 85.3% and specificity 87.5% to predict severe CAP. The agreement analysis between NLR with cut-off point 2.11 and procalcitonin with cut-off point 1 ng/ml showed substantial agreement for determining severe CAP in children (k=0,62; p=0,001).
Conclusions: There was substantial agreement between NLR and procalcitonin for determining severe CAP in children.
Sri Lanka Journal of Child Health, 2022; 51(4): 547-552
How to Cite:
Aryani, I.G.A.D., Mayangsari, A.S.M., Gunawijaya, E., Kardana, M., Putra, I.G.N.S., Hartawan, I.N.B. and Widnyana, A.A.N.K.P., 2022. Agreement between neutrophil/lymphocyte ratio and procalcitonin for determining severe community acquired pneumonia in children. Sri Lanka Journal of Child Health, 51(4), pp.547–552. DOI: http://doi.org/10.4038/sljch.v51i4.10368
Published on
05 Dec 2022.
Peer Reviewed
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