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A hospital based comparative study of the first and second waves of Covid-19 related multi-system inflammatory syndrome in children

Authors:

Bindusha Sasidharan ,

Government Medical College, Thiruvananthapuram, Kerala, IN
About Bindusha
Associate Professor, Department of Paediatrics, SATH
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Sheeja Sugunan,

Government Medical College, Thiruvananthapuram, Kerala
About Sheeja
Associate Professor, Department of Paediatrics, SATH
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K. Monica,

Government Medical College, Thiruvananthapuram, Kerala, IN
About K.
Senior Resident, Department of Paediatrics, SATH
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R. V. Chinchilu,

Government Medical College, Thiruvananthapuram, Kerala, IN
About R. V.
Assistant Professor, Department of Paediatrics, SATH
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H. R. Niyas,

Government Medical College, Thiruvananthapuram, Kerala, IN
About H. R.
Senior Resident, Department of Paediatrics, SATH
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V. H. Sankar

Government Medical College, Thiruvananthapuram, Kerala, IN
About V. H.
Additional Professor, Department of Paediatrics, SATH
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Abstract

Introduction: Studies have shown the differential impact of the second surge of acute Covid-19 infection, across age, clinical outcome and ethnicity. How these factors impact the clinical characteristics and outcome of multisystem inflammatory syndrome in children (MIS-C) is largely unknown.


Objectives: This hospital based comparative study was undertaken to analyse the clinical characteristics and outcomes of patients admitted with MIS-C during the two waves of Covid-19 infection in a tertiary care teaching hospital in South India.


Method: Patients admitted between September 2020 and October 2021 with MIS-C were included in this study. Patient demographics, laboratory values and treatment details were compared between the two surges of COVID 19 related MIS-C. 


Results: Sixty-five children were admitted with MIS-C in the first wave and 73 in the second wave. More children were referred with a diagnosis of MIS-C in the second wave (p=0.001). There was no significant difference in the mean age or male-female ratio between the two waves. A significantly higher proportion of children in the second wave had cervical lymphadenitis (p=0.02). Need for intensive care unit (ICU) admission (p<0.001), shock (p<0.001), respiratory support (p<0.001) and multi-organ involvement (p<0.001) were significantly lower in the second wave. 


Conclusions: A significantly higher proportion of children with MIS-C in the second wave of Covid-19 infection had cervical lymphadenitis. The need for ICU admission, shock, respiratory support and multi-organ involvement were significantly lower in children with MIS-C in the second wave of Covid-19 infection.


Sri Lanka Journal of Child Health, 2022; 51(3): 431-435

How to Cite: Sasidharan, B., Sugunan, S., Monica, K., Chinchilu, R.V., Niyas, H.R. and Sankar, V.H., 2022. A hospital based comparative study of the first and second waves of Covid-19 related multi-system inflammatory syndrome in children. Sri Lanka Journal of Child Health, 51(3), pp.431–435. DOI: http://doi.org/10.4038/sljch.v51i3.10244
Published on 05 Sep 2022.
Peer Reviewed

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