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Original Articles

Effectiveness of isoniazid preventive therapy (IPT) and risk factors for IPT failure in children below 5 years of age who are household contacts of smear positive adult patients with tuberculosis

Authors:

Dina Aristiya Sumarno,

Universitas Airlangga, ID
About Dina
Department of Child Health, Faculty of Medicine
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Retno Asih Setyoningrum ,

Universitas Airlangga, ID
About Retno
Department of Child Health, Faculty of Medicine
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Hari Basuki Notobroto

Universitas Airlangga, ID
About Hari
Department of Biostatistics and Population, Faculty of Public Health
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Abstract

Introduction: Childhood tuberculosis (TB) is yet a major problem in developing countries. Isoniazid preventive therapy (IPT) is recommended for children below 5 years of age who are household contacts of smear positive adult TB patients.


Objectives: To assess effectiveness of the six month IPT therapy and the risk factors for IPT failure in children less than 5 years old who are household contacts of smear positive adult TB patients.


Method: A prospective longitudinal cohort study was carried out in the Surabaya Public Health Centre from January to June 2019 in children below 5 years of age who were household contacts of smear positive adult TB patients and who were given isoniazid for 6 months. Bivariate analysis using Chi-Square test and multivariate analysis were used. p <0.05 was considered significant.


Results: Ninety one children below 5 years of age met the inclusion criteria and were included in study. Efficacy of IPT was 95.5%. In multivariate analysis, the risk factors associated with IPT failure were child contacts living in house without ventilation (p = 0.007) and incomplete IPT (p = 0.007).


Conclusions: Efficacy of IPT in reducing the incidence of TB in children below 5 years of age who were household contacts of smear positive adult TB patients was 95.5%. Low adherence to completion of therapy and unavailability of house ventilation were associated with IPT failure.


Sri Lanka Journal of Child Health, 2022; 51(2): 209-214

How to Cite: Sumarno, D.A., Setyoningrum, R.A. and Notobroto, H.B., 2022. Effectiveness of isoniazid preventive therapy (IPT) and risk factors for IPT failure in children below 5 years of age who are household contacts of smear positive adult patients with tuberculosis. Sri Lanka Journal of Child Health, 51(2), pp.209–214. DOI: http://doi.org/10.4038/sljch.v51i2.10119
Published on 05 Jun 2022.
Peer Reviewed

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