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Original Articles

Vitamin D deficiency and its associated comorbidities in very low birth weight neonates

Authors:

Suresh Kumar Tripathy,

KIIT University, Bhubaneswar, Odisha, IN
About Suresh

Kalinga Institute of Medical Sciences

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Soumini Rath,

KIIT University, Bhubaneswar, Odisha, IN
About Soumini
Kalinga Institute of Medical Sciences
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Manas Kumar Nayak,

KIIT University, Bhubaneswar, Odisha, IN
About Manas
Kalinga Institute of Medical Sciences
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Santosh Kumar Panda

KIIT University, Bhubaneswar, Odisha, IN
About Santosh
Kalinga Institute of Medical Sciences
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Abstract

Objectives: To assess the prevalence of vitamin D deficiency (VDD) among very low birth weight (VLBW) neonates and its associated co-morbidities.


Method: A prospective observational study was carried out at a tertiary care neonatal centre of Odisha, India, from February to November 2018. All VLBW infants admitted within the first 24 hours after birth were included in the study after parental consent. Infants with multiple congenital malformations were excluded. Initial blood samples were collected within the first 24 hours of life and vitamin D estimation was done by chemiluminescence immunoassay. Serum calcium and alkaline phosphatise (ALP) were measured by cresolphthalein complexone and para-nitro phenyl phosphate method respectively. Statistical Package for the Social Sciences version 16 was used for statistical analysis.


Results: Our study included 40 VLBW neonates with a mean birth weight of 1133.95±208.487g and a mean gestational age of 30.60±2.274 weeks. VDD prevalence was 67.5% and mean vitamin D level was 16.906±12.708ng/dl. However, the indirect laboratory parameters of VDD like mean serum calcium, phosphorous and ALP levels were within the normal range. There was higher incidence of respiratory distress syndrome (RDS) and sepsis in babies with VDD.


Conclusions: In this study VDD was found in 67.5% of VLBW babies. Incidences of RDS and neonatal sepsis were greater in babies with VDD.


Sri Lanka Journal of Child Health, 2021; 50(3): 448-452

How to Cite: Tripathy, S.K., Rath, S., Nayak, M.K. and Panda, S.K., 2021. Vitamin D deficiency and its associated comorbidities in very low birth weight neonates. Sri Lanka Journal of Child Health, 50(3), pp.448–452. DOI: http://doi.org/10.4038/sljch.v50i3.9694
Published on 05 Sep 2021.
Peer Reviewed

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