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Clinical profile and laboratory findings of patients with thrombocytopenia in hospital set up: A hospital based prospective study

Authors:

Priyanka Agarwal ,

Institute of Medical Sciences and SUM Hospital, IN
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Dillip Kumar Dash,

Institute of Medical Sciences and SUM Hospital, IN
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Mrinal Sinha,

Institute of Medical Sciences and SUM Hospital, IN
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Mamta Kumari,

Institute of Medical Sciences and SUM Hospital, IN
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Mamta Devi Mohanty,

Institute of Medical Sciences and SUM Hospital
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A S A M Srikant

Institute of Medical Sciences and SUM Hospital, IN
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Abstract

Introduction: Thrombocytopenia is commonly encountered in our routine clinical practice. Causes being numerous,  it poses a challenge in evaluating and treating the patients.

 

Objectives: To determine the causes, clinical profile and outcome of thrombocytopenia in children aged 1 month to 14 years who were admitted in our set up.


Method: This was a prospective study done on 200 patients aged 1 month to 14 years with thrombocytopenia admitted to the Institute of Medical Sciences AND SUM Hospital, Bhubaneshwar, Odisha, India with various complaints, from 01-08-2017 TO 01-08-2019.


Results: Fifty six (28%) children were in the 3-6 year age group. In 116 (58 %) children the thrombocytopenia was in the rainy season. Common causes of thrombocytopenia were dengue (18.5%), sepsis (16.5%) and scrub typhus (16%). Petechiae was the commonest bleeding manifestation (62%) followed by epistaxis (13.7%). Out of 32 cases of scrub typhus 23 (71.8%) had deranged liver function tests. Out of the 8 children that died, one had platelet count ≤10,000/µL, one had platelet count 10,000-20,000/µL while 3 each had platelet counts in the range of 22,000 – 50,000/µL and >50,000/µL respectively   


Conclusions: There was male predominance. The commonest age group was 3-6 years. Thrombocytopenia was more common during the rainy season. Common causes were dengue, septicaemia and scrub typhus. Common clinical presentations were fever, organomegaly, generalised myalgia, lymphadenopathy and headache. Petechiae/Purpura was the most common bleeding manifestation. Mortality rate was 4%.


Sri Lanka Journal of Child Health, 2021; 50(1): 94-102

How to Cite: Agarwal, P., Dash, D.K., Sinha, M., Kumari, M., Mohanty, M.D. and Srikant, A.S.A.M., 2021. Clinical profile and laboratory findings of patients with thrombocytopenia in hospital set up: A hospital based prospective study. Sri Lanka Journal of Child Health, 50(1), pp.94–102. DOI: http://doi.org/10.4038/sljch.v50i1.9409
Published on 05 Mar 2021.
Peer Reviewed

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