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Neonatal sepsis: Bacterial aetiological agents and drug sensitivity pattern in a tertiary hospital in North-Central Nigeria

Authors:

Efe Abolodje ,

Delta State University, Nigeria, NG
About Efe
Delta State University, Nigeria
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Surajudeen Oyeleke Bello,

Dalhatu Araf Specialist Hospital, Nigeria,, NG
About Surajudeen
Dalhatu Araf Specialist Hospital, Nigeria, 
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Esther Audu,

Dalhatu Araf Specialist Hospital, Nigeria,, NG
About Esther
Dalhatu Araf Specialist Hospital, Nigeria, 
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Yusuf Tahir,

Usmanu Danfodiyo University Teaching Hospital, Nigeria, NG
About Yusuf
Usmanu Danfodiyo University Teaching Hospital, Nigeria
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Asmau Ozohu Aliyu,

Dalhatu Araf Specialist Hospital, Nigeria,, NG
About Asmau
Dalhatu Araf Specialist Hospital, Nigeria,
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Shamsudeen Mohammed,

Dalhatu Araf Specialist Hospital, Nigeria,, NG
About Shamsudeen
Dalhatu Araf Specialist Hospital, Nigeria,
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Sunday Ikukpla’si Ozhe

Dalhatu Araf Specialist Hospital, Nigeria,, NG
About Sunday
Dalhatu Araf Specialist Hospital, Nigeria,
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Abstract

Background: Neonatal sepsis is an important cause of neonatal morbidity and mortality in developing countries. Its successful treatment requires a foreknowledge of common aetiological agents and their drug sensitivity pattern. 

Objective: To determine the prevalence of neonatal sepsis among suspected cases, the pathogens responsible for neonatal sepsis and their drug sensitivity pattern in the neonatal unit of Dalhatu Araf Specialist Hospital, Lafia, Nigeria. 

Method: A descriptive cross-sectional study was conducted from 1st January to 31st August 2018. Neonates admitted into the neonatal unit for sepsis had blood taken for culture before commencement of antibiotics. Clinical features of neonates and maternal risk factors for sepsis were documented. 

Results: Out of 106 neonates studied, 65 had confirmed bacterial sepsis giving a prevalence of 61%. Escherichia coli accounted for 29 (45%), Klebsiella pneumoniae for 13 (20%), Staphylococcus aureus for 13 (20%), Coagulase negative Staphylococcus for 13 (20%) and Proteus species for 2 (3%). All four isolates were highly sensitive to ciprofloxacin and gentamycin. Escherichia coli and Klebsiella pneumoniae showed significant resistance to ceftriaxone. 

Conclusions: The commonest cause of neonatal sepsis in the study environment was Escherichia coli. Significant resistance against conventional drugs used in the treatment of neonatal sepsis was noted.

Sri Lanka Journal of Child Health, 2020; 49(2): 125-131

How to Cite: Abolodje, E., Bello, S.O., Audu, E., Tahir, Y., Aliyu, A.O., Mohammed, S. and Ozhe, S.I., 2020. Neonatal sepsis: Bacterial aetiological agents and drug sensitivity pattern in a tertiary hospital in North-Central Nigeria. Sri Lanka Journal of Child Health, 49(2), pp.125–131. DOI: http://doi.org/10.4038/sljch.v49i2.8959
Published on 05 Jun 2020.
Peer Reviewed

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