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Experience with very high dose (8mg/kg/day, maximum 60mg/day) prednisolone for West syndrome in a resource limited setting

Authors:

Ashok Kumar ,

Subharti Medical College, India, IN
About Ashok
Subharti Medical College, India
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Sunil Malik,

Subharti Medical College, India, IN
About Sunil
Subharti Medical College, India
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Saurabh Chopra,

BLK Hospital, India, IN
About Saurabh

BLK Hospital, India

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Ashish Prakash

Subharti Medical College, India, IN
About Ashish
Subharti Medical College, India
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Abstract

Objectives: To assess efficacy of very high dose (8mg/kg/day, maximum 60mg/day) prednisolone in patients with West syndrome.

Method: This was an observational study conducted at a tertiary level hospital from August 2014 to August 2015. Children, aged 2 to 23 months, presenting with infantile spasms with hypsarrhythmia or its EEG variants, were enrolled. Study participants were started on very high dose prednisolone (8 mg/kg/day, maximum 60mg/day). The primary outcome measure was complete cessation of spasms and clearance of hypsarrhythmia on EEG after 2 weeks of prednisolone treatment. The study was approved by the institutional ethical committee. 

Results: Forty children were started on very high dose prednisolone (8 mg/kg/day, maximum 60mg/day) of whom four did not come for the 2 week follow up and were excluded. Response rate in the remaining 36 patients was 55.6% after 2 weeks of steroid therapy Side effects seen during hormone therapy included increased appetite in 29 (80.6%) patients, irritability in 27 (75.0%) patients and weight gain in 26 (72.2%) patients.

Conclusions: Use of a very high dose prednisolone regime (8mg/kg/day, maximum 60mg/day) resulted in a complete cessation of spasms and clearance of hypsarrhythmia on EEG after 2 weeks in 55.6% of children with West syndrome in this study.

Sri Lanka Journal of Child Health, 2018; 47(2): 137-140

How to Cite: Kumar, A. et al., (2018). Experience with very high dose (8mg/kg/day, maximum 60mg/day) prednisolone for West syndrome in a resource limited setting. Sri Lanka Journal of Child Health. 47(2), pp.137–140. DOI: http://doi.org/10.4038/sljch.v47i2.8479
Published on 05 Jun 2018.
Peer Reviewed

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