Original Articles
Experience with very high dose (8mg/kg/day, maximum 60mg/day) prednisolone for West syndrome in a resource limited setting
Authors:
Ashok Kumar ,
Subharti Medical College, India, IN
About Ashok
Subharti Medical College, India
Sunil Malik,
Subharti Medical College, India, IN
About Sunil
Subharti Medical College, India
Saurabh Chopra,
BLK Hospital, India, IN
About Saurabh
BLK Hospital, India
Ashish Prakash
Subharti Medical College, India, IN
About Ashish
Subharti Medical College, India
Abstract
Objectives: To assess efficacy of very high dose (8mg/kg/day, maximum 60mg/day) prednisolone in patients with West syndrome.
Method: This was an observational study conducted at a tertiary level hospital from August 2014 to August 2015. Children, aged 2 to 23 months, presenting with infantile spasms with hypsarrhythmia or its EEG variants, were enrolled. Study participants were started on very high dose prednisolone (8 mg/kg/day, maximum 60mg/day). The primary outcome measure was complete cessation of spasms and clearance of hypsarrhythmia on EEG after 2 weeks of prednisolone treatment. The study was approved by the institutional ethical committee.
Results: Forty children were started on very high dose prednisolone (8 mg/kg/day, maximum 60mg/day) of whom four did not come for the 2 week follow up and were excluded. Response rate in the remaining 36 patients was 55.6% after 2 weeks of steroid therapy Side effects seen during hormone therapy included increased appetite in 29 (80.6%) patients, irritability in 27 (75.0%) patients and weight gain in 26 (72.2%) patients.
Conclusions: Use of a very high dose prednisolone regime (8mg/kg/day, maximum 60mg/day) resulted in a complete cessation of spasms and clearance of hypsarrhythmia on EEG after 2 weeks in 55.6% of children with West syndrome in this study.
Sri Lanka Journal of Child Health, 2018; 47(2): 137-140
How to Cite:
Kumar, A., Malik, S., Chopra, S. and Prakash, A., 2018. Experience with very high dose (8mg/kg/day, maximum 60mg/day) prednisolone for West syndrome in a resource limited setting. Sri Lanka Journal of Child Health, 47(2), pp.137–140. DOI: http://doi.org/10.4038/sljch.v47i2.8479
Published on
05 Jun 2018.
Peer Reviewed
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