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A retrospective analysis of dysglycaemia and its risk factors in a cohort of human immunodeficiency virus infected antiretroviral therapy naïve children in Makurdi, Nigeria

Author:

Emmanuel Anigilaje

Department of Paediatrics, College of Health Sciences, University of Abuja, Nigeria, NG
About Emmanuel

Department of Paediatrics, College of Health Sciences, University of Abuja, Nigeria

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Abstract

Background: Human immunodeficiency virus (HIV) endocrinopathy involving the pancreas manifests clinically as dysglycaemia, including hypoglycaemia and hyperglycaemia. Dysglycaemia increases mortality in sick children, underlying the need for its evaluation and management.

Objective: To assess the prevalence and risk factors of dysglycaemia in a cohort of antiretroviral therapy (ART)-naïve children at the point of enrolment into a paediatric ART clinic of the Federal Medical Centre, Makurdi, Nigeria.

Method: A retrospective cross-sectional study was carried out between June 2010 and June 2012. Hypoglycaemia was defined as random blood glucose level ˂2.2 mmol/l and hyperglycaemia as random blood glucose ˃6.6 mmol/l. Potential risk factors of dysglycaemia were tested for significance in bivariate and multivariate  regression analyses. P-value less than 0.05 was considered to be significant.

Results: 429 children, aged 1-15 years, including 223 males and 206 females were studied. The median age was 5 years. Twelve (2.8%) children had hypoglycaemia and 35 (8.2%) had hyperglycaemia. In multivariate regression analysis, no factor significantly predicted the risk of hypoglycaemia, whereas children co-infected with hepatitis C were at a significant risk of hyperglycaemia (adjusted odds ratio; 2.06, 95% CI; 1.05-8.52, P=0.03).

Conclusions: In this study HIV-infected Nigerian children who were not on ART had a low prevalence of hypoglycaemia but a high prevalence of hyperglycaemia. Hepatitis C co-infection was a significant independent risk factor for hyperglycaemia.

Sri Lanka Journal of Child Health, 2017; 46(3): 248-258

How to Cite: Anigilaje, E., (2017). A retrospective analysis of dysglycaemia and its risk factors in a cohort of human immunodeficiency virus infected antiretroviral therapy naïve children in Makurdi, Nigeria. Sri Lanka Journal of Child Health. 46(3), pp.248–258. DOI: http://doi.org/10.4038/sljch.v46i3.8327
Published on 05 Sep 2017.
Peer Reviewed

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