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Vertical transmission rate of human immunodeficiency virus amid formula-fed infants in a resource-constrained tertiary hospital in Jos, Nigeria

Authors:

T J Igbudu ,

Department of Family Medicine, Benue State University Teaching Hospital (BSUTH), Makurdi, Nigeria, NG
About T J

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O Inyang,

Department of Family Medicine, Plateau State Specialist Hospital, Jos, NG
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R Longmut,

3Department of Family Medicine, Jos University Teaching Hospital, Jos, NG
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L Egwuda,

Department of Family Medicine, Benue State University Teaching Hospital (BSUTH), Makurdi, NG
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BT Utoo

Department of Obstetrics and Gynaecology, BSUTH, Makurdi, NG
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Abstract

Background: Human Immunodeficiency Virus (HIV) can be transmitted from infected mother to her baby.

Objective: To assess transmission rate of HIV from seropositive mothers on highly active anti-retroviral therapy (HAART) to their formula-fed babies.

Method: A cross-sectional study of 65 paired mothers on HAART and their formula-fed babies was carried out. Polymerase chain reaction-deoxyribonucleic acid (PCR-DNA) of the babies was done at six weeks of age. Epi info was used to analyse data.

Results: Mean age of mothers was 30.26 ± 0.5 years. About 73.8% of the paired mothers were diagnosed with HIV before their current pregnancies and 69.2% initiated HAART before their current pregnancies. Duration of HAART use was between three months and two years. Modes of deliveries were caesarean section (15.4%) and vaginal route (84.6%). Only one (1.5%) of the babies was positive to PCR-DNA test at six weeks of age. There was no statistically significant association between the baby’s PCR-DNA at six weeks of age and the mode of delivery (OR-0.0047, CI-95%, Fisher Exact=0.8461) as well as between the time of initiation of HAART by the paired mothers and the paired baby’s PCR-DNA results (RR-0.9778, CI-95%, Fisher Exact=0.6923).

Conclusions: Overall mother to child transmission (MTCT) rate in this study was 1.5%. Use of HAART for more than three months, irrespective of delivery route, is capable of significantly reducing MTCT of HIV even in resource-constrained settings.

Sri Lanka Journal of Child Health, 2015; 44(3): 153-157

How to Cite: Igbudu, T.J., Inyang, O., Longmut, R., Egwuda, L. and Utoo, B., 2015. Vertical transmission rate of human immunodeficiency virus amid formula-fed infants in a resource-constrained tertiary hospital in Jos, Nigeria. Sri Lanka Journal of Child Health, 44(3), pp.153–157. DOI: http://doi.org/10.4038/sljch.v44i3.8012
Published on 12 Sep 2015.
Peer Reviewed

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