Objective To study a series of cases of acquired platelet dysfunction with eosinophilia (APDE).
Design A prospective study of cases of APDE admitted to a paediatric unit from August 1994 to December 2000.
Setting Lady Ridgeway Hospital for Children, Colombo.
Method Children with suspected APDE were investigated and analysed. Investigations included haemoglobin, white cell count, bleeding time, clotting time, platelet count, prothrombin time, partial thromboplastin time, ESR, peripheral blood film, clot retraction, platelet aggregation test, stools full report, filarial antibody test and toxocara antibody test. The platelet aggregation test was repeated after 6 months.
Results There were 12 children with suspected APDE. The male: female ratio was 1.4:1. The ages ranged from 16 months to 10 years. Hess test was negative in all children. The absolute eosinophil count ranged from 1.9-7.8 x 109/l. The bleeding time was prolonged in 58% cases. The platelet aggregation test was abnormal in all cases. The filarial antibody test was positive in 17% cases. All other investigations were normal. The platelet aggregation test normalised after 6 months in all cases.
Conclusion APDE is a not uncommon cause of nonthrombocytopenic purpura in Sri Lanka. It is a benign condition with a mild, transient haemorrhagic diathesis and spontaneous recovery occurs within 6 months.
Sri Lanka Journal of Child Health, 2002; 31: 89-90